AzaClear® is the result of genuine dermatologic scientific research and recent advances in cosmetic chemistry. Our patented and unique SynergyE cosmetic base has also been recognized in medical journals.
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AzaClear® is a unique combination of naturally derived ingredients, designed to address the visible effects of problem or aging skin. Azelaic acid has long been known for its beneficial cosmetic effects on the skin. Products that contain azelaic acid as their primary ingredient, however, have been found to be both helpful to skin and potentially irritating. Other skin treatment creams such as retinoids, retinol and benzoyl peroxide suffer from the same potential for irritation. The AzaClear® formula contains a high concentration of azelaic acid and does not irritate the skin.1
Complexing azelaic acid + niacinamide is another first. We call our patented combination, SynergyE™. Synergy occurs when the addition of several ingredients results in an effect greater than expected. SynergyE™ is a patented emollient cosmetic base complexing and micronizing azelaic acid with niacinamide in combination with the moisturizing effects of glycerin. AzaClear® is soothing to the skin and encourages hydration. Now AzaClear Day Therapy Micro is ultra micronized to reduce the size of azelaic acid particles to less than 20um! Ultra micronization increases the penetration of AzaClear for even more impressive and faster results.
AzaClear® is free of fragrance, masking fragrances, colorants, dyes, hydroquinone, or formalin releasing biocides. There is no animal testing in the manufacturing process.
A product's safety, efficacy and stability are a direct result of the ingredients chosen, how the ingredients interact and the quality of the manufacturing process. From the outset, our mission was for AzaClear® to contain quality ingredients and to be produced in a FDA licensed facility that meets GMP (good manufacturing practices). Although the GMP practices are required of pharmaceutical manufacturing they are not required by the FDA for production of cosmetic or cosmeceutical products.
Azaclear does not contain fragrances, phalates or parabens. Our company supports the environmental working group as well as the FDA in their fight toward greater regulation and transparency for ingredients in cosmetics and creams. One of our founders in addition to being a dermatologist, is also a specialist in environmental health and toxic chemical exposure. Our ingredients were designed to ensure patient safety.
The SynergyE™ Difference
AzaClear® is the result of years of dermatologic research to improve the effects of both azelaic acid and niacinamide while creating a product that was hydrating. AzaClear® not only supports the skin's hydration and barrier function, it remains non-comedogenic. Previous formulations containing azelaic acid have used either sd alcohol or propylene glycol to solubilize and dissolve azelaic acid into a cream or gel base, thus increasing the potential for skin irritation. AzaClear® utilizes a proprietary and patent-pending process to shrink the size of azelaic acid and niacinamide particles into micron sized droplets and then envelop these micronized particles with the hydrating effects of non-animal derived glycerin. We call the compound, SynergyE™. It improves and creates synergy between the well documented and favorable skin effects of both azelaic acid and niacinamide while preserving the skin's epidermal barrier function.
The AzaClear® Eye Serum (patent-pending) expands the SynergyE™ family of products from Epikinetics Pharma LLC. Azelaic Acid, niacinamide and glycerin are complexed with cyclodextrin to improve the product penetration while reducing to an absolute minimum, the potential for irritation. This product is designed to use safely around the eye and benefit from the actions of azelaic acid in this very delicate area.
The production of cyclodextrins is relatively simple and involves treatment of ordinary starch with a set of enzymes. Cyclodextrins are able to form host-guest complexes with hydrophobic molecules given the unique nature imparted by their structure. AzaClear® Eye Serum with cyclo-azelaic acid, forms a complex of azelaic acid, enveloped and protected by a circle of cyclodextrin. This allows for more azelaic acid to be dissolved in the water based eye serum while encouraging skin effects and hydration. Cyclodextrins have also been used to solubilize hydrophobic drugs in pharmaceutical applications, and crosslink to form polymers used for enhanced skin effects.
Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe (GRAS) by the FDA.
 Thatiparti, Thimma R.; Shoffstall, Andrew J.; Von Recum, Horst A. (2010). "Cyclodextrin-based device coatings for affinity-based release of antibiotics". Biomaterials 31 (8): 2335–47. PMID 20022369.
 "Generally Recognized as Safe (GRAS)". Fda.gov. Retrieved 2013-03-17.
A naturally occurring organic substance. It is a dicarboxylic acid found in wheat, rye and barley. Azelaic acid is therefore also a dietary constituent. Azelaic acid is known for it's powerful cosmetic benefits and has been used as a cosmetic, cosmeceutical and pharmaceutical agent.
Niacinamide is a water-soluble component of the vitamin B group. It does not cause skin flushing like niacin. Niacinamide is a coenzyme in a wide variety of cellular functions. Vitamins such as niacinamide have been noted to be anti-inflammatory.
Glycerin moisturizers and lubricates the skin, promoting skin softness and smoothness. It is colorless and odorless and widely used in pharmaceutical products.
1. In a study n=71 subjects aged 21-65 with Fitzpatrick skin types II-VI, no test subjects demonstrated skin irritation. Results on file, Epikinetics Pharma, llc.